Aman completed his PhD with Prof. Anil Grover at the University of Delhi South Campus, where he investigated the heat shock response in plants. For his doctoral research, he was awarded the Indian National Science Academy (INSA) Young Scientist Medal. He then moved to The Scripps Research Institute, La Jolla, for postdoctoral work with Dr. Vincent P. Mauro, focusing on the role of non-canonical translation initiation factors in translation reinitiation.
​
He subsequently joined the laboratory of Prof. Randy Hampton at UC San Diego, where he studied how chaperones and the ubiquitin–proteasome system coordinate in the cytoplasm to regulate the degradation of misfolded proteins. This work led to the proposal of the “Folding Escape Model,” which describes a kinetic competition between protein folding and ubiquitination. In this framework, E3 ligase-mediated ubiquitination governs substrate triage, creating a “race” between successful folding and degradation. The model further suggests that deubiquitinases act alongside E3 ligases to fine-tune degradation kinetics and modulate the timing of these decisions.
​
Returning to India as an INSA Young Scientist, Aman worked at the National Centre for Biological Sciences (NCBS), Bengaluru, in collaboration with Prof. Mani Ramaswami (Trinity College Dublin), where he focused on protein quality control in cellular stress and neurodegeneration. Prior to joining MIRM, MAHE–Bengaluru in March 2024, he served as a faculty member at the Institute of Bioinformatics and Applied Biotechnology (IBAB). He was awarded the India Alliance DBT–Wellcome Trust Intermediate Fellowship in December 2023.
​
Outside the lab, Aman enjoys long, traffic-free drives—with his daughter Anaya—best paired with good music and the occasional food stop along the way.
